Cancer cells seem to exploit mechanisms that evolve as part of physiological tolerance, which is a complementary and often beneficial form of defense. The study of physiological systems of tolerance can therefore provide insights into the development of a state of host tolerance of cancer, and how to break it. Analysis of these models has the potential to improve our understanding of existing immunological therapeutic targets, and help to identify future targets and rational therapeutic combinations. The treatment of cancer with (...) immune checkpoint inhibitors aims to reverse the progression to tolerance of cancer, and achieve an immunogenic, rather than tolerogenic, homeostasis. Broadening the efficacy and durability of checkpoint inhibitors focuses on reversing tolerance and stimulating immunogenicity in the cancer, host, and environment. Two examples of important physiological states of tolerance that may inform tolerance of cancer are microbial infection and placental reproduction. These states of tolerance result from bilateral shaping of host and non‐self, akin to immunoediting in cancer, and offer reliable models to study the immune tolerance paradigm. (shrink)

The study tests the hypothesis that conditional probability judgments can be influenced by causal links between the target event and the evidence even when the statistical relations among variables are held constant. Three experiments varied the causal structure relating three variables and found that (a) the target event was perceived as more probable when it was linked to evidence by a causal chain than when both variables shared a common cause; (b) predictive chains in which evidence is a cause of (...) the hypothesis gave rise to higher judgments than diagnostic chains in which evidence is an effect of the hypothesis; and (c) direct chains gave rise to higher judgments than indirect chains. A Bayesian learning model was applied to our data but failed to explain them. An explanation-based hypothesis stating that statistical information will affect judgments only to the extent that it changes beliefs about causal structure is consistent with the results. (shrink)

Functional diversity holds the promise of understanding ecosystems in ways unattainable by taxonomic diversity studies. Underlying this promise is the intuition that investigating the diversity of what organisms actually do—i.e. their functional traits—within ecosystems will generate more reliable insights into the ways these ecosystems behave, compared to considering only species diversity. But this promise also rests on several conceptual and methodological—i.e. epistemic—assumptions that cut across various theories and domains of ecology. These assumptions should be clearly addressed, notably for the sake (...) of an effective comparison and integration across domains, and for assessing whether or not to use functional diversity approaches for developing ecological management strategies. The objective of this contribution is to identify and critically analyze the most salient of these assumptions. To this aim, we provide an “epistemic roadmap” that pinpoints these assumptions along a set of historical, conceptual, empirical, theoretical, and normative dimensions. (shrink)

Watershed planning has typically been approached as a technical problem in which water quality and quantity as influenced by the hydrology, topography, soil composition, and land use of a watershed are the significant variables. However, it is the human uses of land and water as resources that stimulate governments to seek planning. For the past decade or more, many efforts have been made to create democratic planning processes, which, it is hoped, will be viewed as legitimate by those the plans (...) regulate. This article uses a case study of the Cache River watershed in southernmost Illinois to analyze the complicated historical and political economic context of a specific watershed planning process that occurred from 1993 through 1995. This article assesses the claims made about the democratic, grass-roots, deliberative nature of the planning process and casts doubt on the legitimacy of its outcomes. It also proposes an alternative form of governance that would be both democratic and capable of generating outcomes viewed as legitimate by most affected parties. (shrink)

This book is a collection of secondary essays on America's most important philosophic thinkers—statesmen, judges, writers, educators, and activists—from the colonial period to the present. Each essay is a comprehensive introduction to the thought of a noted American on the fundamental meaning of the American regime.

In Hegel's Critique of Liberalism , Steven B. Smith examines Hegel's critique of rights-based liberalism and its relevance to contemporary political concerns. Smith argues that Hegel reformulated classic liberalism, preserving what was of value while rendering it more attentive to the dynamics of human history and the developmental structure of the moral personality. Hegel's goal, Smith suggests, was to find a way of incorporating both the ancient emphasis on the dignity and even architectonic character of political life with the (...) modern concern for freedom, rights, and mutual recognition. Smith's insightful analysis reveals Hegel's relevance not only to contemporary political philosophers concerned with normative issues of liberal theory but also to political scientists who have urged a revival of the state as a central concept of political inquiry. (shrink)

Preface -- Why political philosophy? -- Antigone and the politics of conflict -- Socrates and the examined life -- Plato on justice and the human good -- Aristotle's science of regime politics -- The politics of the Bible -- Machiavelli and the art of political founding -- Hobbes's new science of politics -- Locke and the art of constitutional government -- Rousseau on civilization and its discontents -- Tocqueville and the dilemmas of democracy -- In defense of patriotism.

In a recent issue of Faith and Philosophy, Timothy Pawl and Kevin Timpe seek to respond to the so-called “Problem of Heavenly Freedom,” the problem ofexplaining how the redeemed in heaven can be free yet incapable of sinning. In the course of offering their solution, they argue that compatibilism is inadequateas a solution because it (1) undermines the free will defense against the logical problem of evil, and (2) exacerbates the problem of evil by making God the “author of sin.” (...) In this paper, I respond to these charges and argue that compatibilism can offer a satisfactory explanation for the sinlessness of the redeemed in heaven. I also raise some problems for Pawl’s and Timpe’s incompatibilist solution. (shrink)

Scott Davison has raised some challenges to my case against the commensurability of meticulous providence and what I call Scheme-B Molinism, the view that God formulates his plan for the course of history consequent to his cognizance of the true counterfactuals of freedom. In this rejoinder, I attempt to clarify certain points of my argument and respond to his criticisms by showing that he has not dealt adequately with the relevant biblical texts or alleviated the worry that the Molinist view (...) of providence reduces God to just “choosing which movie to play.”. (shrink)

When it comes to contemporary philosophical problems, metaphysical idealism-or Berkeleyan immaterialism-is not taken seriously by most philosophers, not to mention the typical Christian layperson. This state of affairs deserves some attempt at rectification, since Idealism has considerable explanatory power as a metaphysical thesis and provides numerous practical and theoretical benefits. Such thinkers as George Berkeley and Jonathan Edwards believed that Idealism is especially amenable to a Christian perspective, both because it provides a plausible way of conceptualizing the world from a (...) theistic standpoint and because it effectively addresses skeptical challenges to the Christian faith. The contributors to this volume explore a variety of ways in which the case can be made for this claim, including potential solutions to philosophical problems related to the nature of time, the ontology of physical objects, the mind-body problem, and the nature of science. (shrink)

Problems in Epistemology and Metaphysics takes a pro and con approach to two central philosophical topics. Each chapter begins with a question: Can We Have Knowledge? How are Beliefs Justified? What is the mind? Contemporary philosophers with opposing viewpoints are then paired together to argue their position and raise problems with conflicting standpoints. Alongside an up-to-date introduction to a core philosophical stance, each contributor provides a critical response to their opponent and clear explanation of their view. Discussion questions are included (...) at the end of each chapter to guide further discussion. With chapters covering core questions surrounding religious beliefs, scientific knowledge, truth, being and reality, this is a comprehensive introduction to debates lying at the heart of what we know, how we know it and the nature of the world we live in. (shrink)

In a recent commentary, Memmert critiqued claims that attentional misdirection is directly analogous to inattentional blindness and cautioned against assuming too close a similarity between the two phenomena. One important difference highlighted in his analysis is that most lab-based inductions of IB rely on the taxing of attention through a demanding primary task, whereas attentional misdirection typically involves simply the orchestration of spatial attention. The present commentary argues that, rather than reflecting a complete dissociation between IB and attentional misdirection, this (...) difference highlights potential grounds for delineating mechanistically distinct forms of IB: spatial inattentional blindness, which stems from the covert misallocation of spatial attention, and central inattentional blindness, which stems from disruption or preoccupation of perceptual mechanisms that interface with higher-level processes such as working memory. Recognition of such distinctions can help situate theoretical understanding of IB more firmly within the context of the broader attention literature. (shrink)

George Berkeley is famous for the metaphysical principle esse is percipi or percipere. Many Berkeleyan idealists take this principle to be incompatible with Platonic realism about abstract objects, and thus opt either for nominalism or divine conceptualism on which they are construed as divine ideas. In this paper, I argue that Berkeleyan idealism is consistent with a Platonic realism in which abstracta exist outside the divine mind. This allows the Berkeleyan to expand Berkeley’s principle to read: esse is percipi or (...) percipere or abstractum. (shrink)

Adam Omelianchuk argues that my defense of the distinction between woman’s equality in being and subordinate role fails. I respond that his case misses the point of certain aspects of my argument, that it begs the main question, and that it depends upon an unclear notion of metaphysical equality/inferiority.

Theists believe that God is eternal, but they differ as to just what God's eternality means . The traditional, historic view of most Christian philosophers is that eternality means that God is timeless. He is ‘outside’ of time and not subject to any kind of temporal change. Indeed, God is the creator of time. Lets call this view divine timelessness.

Molinism entails that God cannot actualize just any possible world because God has no control over what counterfactuals of freedom (CFs) are true. This fact confronts the Molinist with a dilemma. If God has a plan for the course of history logically antecedent to his cognizance of the true CFs, then God would have been implausibly lucky if any actualizable world corresponded to his plan. If, on the other hand, God did not have a plan for the course of history (...) antecedent to his cognizance of the true CFs, then Molinism is incommensurate with a meticulous view of providence. (shrink)

The Molinist doctrine that God has middle knowledge requires that God knows the truth-values of counterfactuals of freedom, propositions about what free agents would do in hypothetical circumstances. A well-known objection to middle knowledge, the grounding objection, contends that counterfactuals of freedom have no truth-value because there is no fact to the matter as to what an agent with libertarian freedom would do in counterfactual circumstances. Molinists, however, have offered responses to the grounding objection that they believe are adequate for (...) maintaining the coherence of middle knowledge. I argue that these responses to the grounding objection are not adequate, and that what I call the ‘generic grounding objection’ still poses a serious challenge to middle knowledge. (shrink)

Social scientists have long examined the changing role of the individual, and the influence of individualism in social and economic arrangements as well as behavioral decisions. With respect to co-operative behavior among farmers, however, the ideology of individualism has been little theorized in terms of its relationship to the longstanding virtue of independence. This paper explores this relationship by combining analysis of historical literature on the agricultural cooperative movement with the accounts of contemporary English farmers. I show that the virtue (...) of independence is deployed to justify a variety of cooperative and non-cooperative practices and that, despite apparently alternative interpretations, independence is most often conflated with individualistic premises. That conflation, I argue, leads farmers to see their neighbors as natural competitors: as those from whom which independence must be sought. This has the effect of masking the structural dependencies which farmers face and limits the alternatives available to them to realize a view of independence that is maintained, rather than opposed, by interdependent collective action. Thus perceived, individualism is an ideological doctrine that succeeds by appealing to the virtue of independence, while simultaneously denying its actual realization. (shrink)

This paper elaborates on an intrinsically quantum approach to gravity, which begins with a general framework for quantum mechanics and then seeks to identify additional mathematical structure on Hilbert space that is responsible for gravity and other phenomena. A key principle in this approach is that of correspondence: this structure should reproduce spacetime, general relativity, and quantum field theory in a limit of weak gravitational fields. A central question is that of “Einstein separability,” and asks how to define mutually independent (...) subsystems, e.g. through localization. Familiar definitions involving tensor products or operator subalgebras do not clearly accomplish this in gravity, as is seen in the correspondence limit. Instead, gravitational behavior, particularly gauge invariance, suggests a network of Hilbert subspaces related via inclusion maps, contrasting with other approaches based on tensor-factorized Hilbert spaces. Any such localization structure is also expected to place strong constraints on evolution, which are also supplemented by the constraint of unitarity. (shrink)

Baruch de Spinoza (1632-1677)--often recognized as the first modern Jewish thinker--was also a founder of modern liberal political philosophy. This book is the first to connect systematically these two aspects of Spinoza's legacy. Steven B. Smith shows that Spinoza was a politically engaged theorist who both advocated and embodied a new conception of the emancipated individual, a thinker who decisively influenced such diverse movements as the Enlightenment, liberalism, and political Zionism. Focusing on Spinoza's Theologico-Political Treatise, Smith argues that Spinoza (...) was the first thinker of note to make the civil status of Jews and Judaism (what later became known as the Jewish Question) an essential ingredient of modern political thought. Before Marx or Freud, Smith notes, Spinoza recast Judaism to include the liberal values of autonomy and emancipation from tradition. Smith examines the circumstances of Spinoza's excommunication from the Jewish community of Amsterdam, his skeptical assault on the authority of Scripture, his transformation of Mosaic prophecy into a progressive philosophy of history, his use of the language of natural right and the social contract to defend democratic political institutions, and his comprehensive comparison of the ancient Hebrew commonwealth and the modern commercial republic. According to Smith, Spinoza's Treatise represents a classic defense of religious toleration and intellectual freedom, showing them to be necessary foundations for political stability and liberal regimes. In this study Smith examines Spinoza's solution to the Jewish Question and asks whether a Judaism, so conceived, can long survive. (shrink)

The essays of The Cambridge Companion to Leo Strauss provide a comprehensive and non-partisan survey of the major themes and problems that constituted Strauss's work.

Gallup Polls have reported on the perceived ethics of various professions in the US since 1976. Clergymen and pharmacists were consistently identified as two of the most ethical professionals in the 1980''s and 1990''s. Business executives have not fared well in these polls and have not been rated among the top ten most ethical professions in any of the years the poll was taken. Ethical codes have not done much to belay the perception that the US business executive is not (...) very ethical. Whether the Sarbanes-Oxley Act will impact the ethical behavior of business executives remains to be seen. (shrink)

Most readers of Spinoza treat him as a pure metaphysician, a grim determinist, or a stoic moralist, but none of these descriptions captures the author of the _Ethics, _argues Steven B. Smith in this intriguing book. Offering a new reading of Spinoza’s masterpiece, Smith asserts that the Ethics is a celebration of human freedom and its attendant joys and responsibilities and should be placed among the great founding documents of the Enlightenment. Two aspects of Smith’s book distinguish it from (...) other studies. It treats the famous “geometrical method” of the _Ethics _as_ _a form of moral rhetoric, a model for the construction of individuality. And it presents the _Ethics _as_ _a companion to Spinoza’s major work of political philosophy, the _Theologico-Political Treatise, _each work helping to explore the problem of freedom. Affirming Spinoza’s centrality for both critics and defenders of modernity, the book will be of value to students of political theory, philosophy, and intellectual history. (shrink)

In this paper, I present an argument to show that the doctrine of divine temporality (the view that God is in time, but everlastingly eternal) is incoherent. The doctrine of divine temporality entails that God has traversed an actually infinite series of moments in order to reach the present. But I show that an actually infinite series of moments cannot be traversed. Hence, God could not have traversed his infinite past to reach the present. Therefore, the doctrine of divine temporality (...) is necessarily false. I defend this argument against various responses and objections. (shrink)

Critics of the doctrine of eternal punishment may charge that this doctrine constitutes a horrendous evil unworthy of a perfectly good and loving God in that those experiencing eternal torment have lives not worth living. I respond to the problem of hell as a horrendous evil by arguing, first, that it is not clear that eternal torment constitutes a horrendous evil; and, second, that by adding to the traditional doctrine of hell the Christian belief in human sinfulness and our just (...) desert of eternal punishment, God’s existence is compatible with the existence of persons who have lives not worth living. (shrink)